Regulation of food intake by neuropeptide Y in goldfish
| dc.contributor.author | Narnaware, Yuwaraj | |
| dc.contributor.author | Peyon, Pierre P. | |
| dc.contributor.author | Lin, Xinwei | |
| dc.contributor.author | Peter, Richard E. | |
| dc.date.accessioned | 2022-07-04 | |
| dc.date.accessioned | 2022-10-12T21:20:26Z | |
| dc.date.available | 2022-10-12T21:20:26Z | |
| dc.date.issued | 2000 | |
| dc.description.abstract | In mammals, neuropeptide Y (NPY) is a potent orexigenic factor. In the present study, third brain ventricle (intracerebroventricular) injection of goldfish NPY (gNPY) caused a dose-dependent increase in food intake in goldfish, and intracerebroventricular administration of NPY Y1-receptor antagonist BIBP-3226 decreased food intake; the actions of gNPY were blocked by simultaneous injection of BIBP-3226. Goldfish maintained on a daily scheduled feeding regimen display an increase in NPY mRNA levels in the telencephalon-preoptic area and hypothalamus shortly before feeding; however, a decrease occured in optic tectum-thalamus. In both fed and unfed fish, brain NPY mRNA levels decreased after scheduled feeding. Restriction in daily food ration intake for 1 wk or food deprivation for 72 h resulted in increased brain NPY mRNA levels. Results from these studies demonstrate that NPY is a physiological brain signal involved in feeding behavior in goldfish, mediating its effects, at least in part, through Y1-like receptors in the brain. | |
| dc.description.uri | https://library.macewan.ca/cgi-bin/SFX/url.pl/DMJ | |
| dc.identifier.citation | Narnaware, Y. K., Peyon, P., Lin, X. W., & Peter, R. E. (2000). Regulation of food intake by neuropeptide Y in goldfish. American Journal of Physiology, 279(3), R1025-R1034. https://doi.org/10.1152/ajpregu.2000.279.3.R1025 | |
| dc.identifier.doi | https://doi.org/10.1152/ajpregu.2000.279.3.R1025 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14078/2743 | |
| dc.language | English | |
| dc.language.iso | en | |
| dc.rights | All Rights Reserved | |
| dc.subject | feeding | |
| dc.subject | gene expression | |
| dc.subject | growth hormone | |
| dc.subject | brain | |
| dc.title | Regulation of food intake by neuropeptide Y in goldfish | en |
| dc.type | Article |